Activation of spinal cord microglia and astrocytes is a common phenomenon in nerve injury
pain models and is thought to exacerbate pain perception. Following a nerve injury, a …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Studies suggest that astrocytes and microglia in the spinal cord are involved in the
development of persistent pain induced by tissue inflammation and nerve injury. However …

Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of
study on the neuronal processing of pain, mechanisms underlying the creation and …

Development of next-generation analgesics requires a better understanding of the
molecular and cellular mechanisms underlying pathological pain. Accumulating evidence …

Bone cancer pain is a common and disruptive symptom in cancer patients. In cancer pain
animal models, massive reactive astrogliosis in the dorsal horn of the spinal cord has been …

Pain is classically viewed as being mediated solely by neurons, as are other sensory
phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain …

Mounting evidence supports the hypothesis that spinal microglia modulate the development
and maintenance of some chronic pain states. Here we examined the role of spinal …

Management of chronic pain is a real challenge, and current treatments that focus on
blocking neurotransmission in the pain pathway have resulted in limited success. Activation …

Over the last decade, a series of studies has demonstrated that glia in the central nervous
system play roles in many aspects of neuronal functioning including pain processing …