Parkinson's disease (PD) is a neurodegenerative condition which causes a characteristic
movement disorder secondary to loss of dopaminergic neurons in the substanitia nigra. The …

Motor dysfunctions in Parkinson's disease are considered to be primarily due to the
degeneration of dopaminergic neurons in the substantia nigra pars compacta …

Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders that
despite several options for drug treatment leaves patients severely handicapped after …

Current approaches to cell replacement therapy in Parkinson's disease are strongly focused
on the dopamine system, with the view that restoring dopaminergic inputs in a localized and …

Treating neurodegenerative diseases with cell transplantation has been within reach since
the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain …

Over the past three decades, significant progress has been made in the development of
potential regenerative cell-based therapies for neurodegenerative disease, with most …

The treatment of Parkinson's disease (PD) has for over 50 years relied on dopaminergic
therapies that are highly effective especially in the early years of the condition, but ultimately …

Early clinical trials designed to treat Parkinson's disease by transplantation of fetal tissue
containing dopamine neuron precursors yielded promising results, but the approach retains …

Neuronal degeneration within the substantia nigra and the loss of the dopaminergic nigro-
striatal pathway are the major hallmarks of Parkinson's disease (PD). Grafts of foetal ventral …

Damage to the central nervous system was once considered irreparable. However, there is
now growing optimism that neural transplant therapies may one day enable complete circuit …