Cerebral small vessel disease (cSVD) comprises pathological processes of the small
vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or …

Alzheimer's disease (AD) and cerebral small vessel disease (cSVD) are the two main
causes of dementia with blood–brain barrier (BBB) breakdown being a common contributor …

Introduction Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-
brain barrier (BBB) leakage may be important in SVD-induced brain damage. Methods We …

Blood–brain barrier (BBB) leakage increases with age and is involved in the
pathophysiology of cerebral small vessel disease (cSVD). We examined the relationship …

Background and Purpose—Increased blood–brain barrier (BBB) permeability occurs in
cerebral small vessel disease. It is not known if BBB changes predate progression of small …

Objective: As blood–brain barrier (BBB) dysfunction may occur in normal aging but may also
play a pivotal role in the pathophysiology of cerebral small vessel disease (cSVD), we used …

Background Blood-brain barrier (BBB) breakdown, as an early biomarker for vascular mild
cognitive impairment (vMCI), has only been validated by a few studies. The aim of this study …

Blood-brain barrier (BBB) separates the systemic circulation and the brain, regulating
transport of most molecules to protect the brain microenvironment. Multiple structural and …

Objective To investigate the link between blood-brain-barrier (BBB) permeability and
cerebral blood flow (CBF) and the relation with white matter hyperintensities (WMH) in …

Blood-brain barrier (BBB) leakage is considered an important underlying process in both
cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). The objective of this …