Chiral peptide nucleic acid monomers (PNAM) with modified backbones

AR Katritzky, T Narindoshvili - Organic & biomolecular chemistry, 2008 - pubs.rsc.org
Convenient high yielding syntheses of optically pure PNAMs comprising L-or D-serine, L-
lysine and L-arginine units linked to thymine or Cbz-cytosine are described. Simple workup …

[引用][C] A convenient synthesis of chiral peptide nucleic acid (PNA) monomers

L Kosynkina, W Wang, TC Liang - Tetrahedron Letters, 1994 - Elsevier
A Convenient Synthesis Of Chiral Peptide Nucleic Acid (PNA) Monomers Page 1 Tetmkdmt
Latters, Vol. 35, NO. 29. pp. 5173-5176, 1994 El.3evicr Scieaw Ltd Printed in OMt Britain …

Synthesis of new chiral peptide nucleic acid (PNA) monomers

B Falkiewicz, W Wiśniowski… - … and Nucleic Acids, 2001 - Taylor & Francis
Full article: SYNTHESIS OF NEW CHIRAL PEPTIDE NUCLEIC ACID (PNA) MONOMERS
Skip to Main Content Taylor and Francis Online homepage Taylor and Francis Online …

Synthesis and binding affinity of a chiral PNA analogue

Y Li, T Jin, K Liu - Nucleosides, Nucleotides and Nucleic Acids, 2001 - Taylor & Francis
The synthesis of a chiral peptide nucleic acid (PNA), which is composed of N-aminoethyl-cis-
4-nucleobase-L-proline units, was described. The chiral PNA monomers containing all four …

Synthesis and properties of chiral peptide nucleic acids with a N-aminoethyl-D-proline backbone

T Vilaivan, C Khongdeesameor… - Bioorganic & medicinal …, 2000 - Elsevier
A synthon of d-proline substituted at the 4-position by thymine and at N by a flexible
aminoethyl linker, has been used to prepare a novel chiral peptide nucleic acid (cPNA) with …

Synthesis of achiral and chiral peptide nucleic acid (PNA) monomers using Mitsunobu reaction

B Falkiewicz, AS Kołodziejczyk, B Liberek… - Tetrahedron, 2001 - Elsevier
Peptide nucleic acids (PNAs) are intensively studied DNA analogues. We elaborated an
efficient procedure for the synthesis of N-, C-protected pseudodipeptides with a reduced …

Synthesis of new chiral peptide nucleic acid (PNA) monomers by a simplified reductive animation method

B Falkiewicz, K Kowalska… - … Nucleotides & Nucleic …, 1999 - Taylor & Francis
The aim of this work was the preparation of four new peptide nucleic acid (PNA) monomer
backbone by reductive animation of Nα-Boc-protected chiral amino aldehydes, derived from …

Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone

T Sugiyama, A Kittaka - Molecules, 2012 - mdpi.com
A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate
backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and …

Fast, solid‐phase synthesis of chiral peptide nucleic acids with a high optical purity by a submonomeric strategy

S Sforza, T Tedeschi, R Corradini… - European Journal of …, 2003 - Wiley Online Library
The solid‐phase synthesis of chiral peptide nucleic acids (PNAs) usually results in partial
epimerization of the products, since the α‐nitrogen atom of the amino acid is involved in an …

Chiral analogues of peptide nucleic acids: synthesis of 4-aminoprolyl nucleic acids and DNA complementation studies using UV/CD spectroscopy

BP Gangamani, VA Kumar, KN Ganesh - Tetrahedron, 1999 - Elsevier
This paper describes chemical synthesis of prolyl PNAs which are a class of
conformationally constrained chiral PNA analogues. The monomers are derived from …