The S100B protein in biological fluids: more than a lifelong biomarker of brain distress

F Michetti, V Corvino, MC Geloso… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …

The S100B story: from biomarker to active factor in neural injury

F Michetti, N D'Ambrosi, A Toesca… - Journal of …, 2019 - Wiley Online Library
S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …

The S100B protein: A multifaceted pathogenic factor more than a biomarker

F Michetti, ME Clementi, R Di Liddo, F Valeriani… - International Journal of …, 2023 - mdpi.com
S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system.
Its levels in biological fluids are recognized as a reliable biomarker of active neural distress …

The serum S100B concentration is age dependent

LVC Portela, ABL Tort, DV Schaf, L Ribeiro… - Clinical …, 2002 - academic.oup.com
S100B is a 21-kDa calcium-binding protein produced and released primarily by astrocytes in
the central nervous system (CNS), where it exerts neurotropic and gliotropic actions (1) …

A simple, sensitive and widely applicable ELISA for S100B: methodological features of the measurement of this glial protein

MC Leite, F Galland, G Brolese, MC Guerra… - Journal of Neuroscience …, 2008 - Elsevier
S100B expression, particularly extracellular S100B, is used as a parameter of glial activation
and/or death in several situations of brain injury. Several immunoassays for S100B …

S100B in brain damage and neurodegeneration

M Rothermundt, M Peters, JHM Prehn… - … research and technique, 2003 - Wiley Online Library
S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …

S100B protein in biological fluids: a tool for perinatal medicine

F Michetti, D Gazzolo - Clinical Chemistry, 2002 - academic.oup.com
The diagnosis of perinatal insults currently relies on adequate documentation of general
medical and obstetric factors and on radiologic and laboratory assessments. The …

S100B in neuropathologic states: the CRP of the brain?

J Sen, A Belli - Journal of neuroscience research, 2007 - Wiley Online Library
In recent years there has been a proliferation of interest in the brain‐specific protein S100B,
its many physiologic roles, and its behaviour in various neuropathologic conditions. Since …

[PDF][PDF] Usefulness of S100B protein in neurological disorders

T Yardan, AK Erenler, A Baydin, K Aydin… - JPMA-Journal of the …, 2011 - researchgate.net
In recent years, there has been an increased interest in the clinical use of brain markers. The
S100B is a calciumbinding peptide and is used as a parameter of glial activation and/or …

Extracranial sources of S100B do not affect serum levels

N Pham, V Fazio, L Cucullo, Q Teng, P Biberthaler… - PloS one, 2010 - journals.plos.org
S100B, established as prevalent protein of the central nervous system, is a peripheral
biomarker for blood-brain barrier disruption and often also a marker of brain injury. However …