Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

B Malengier-Devlies, J Filtjens, K Ahmadzadeh… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural
killer (NK) cells play an important role in innate immune responses to viral infections. Here …

[HTML][HTML] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

B Krämer, R Knoll, L Bonaguro, M ToVinh, J Raabe… - Immunity, 2021 - cell.com
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …

Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020

C Manickam, S Sugawara, RK Reeves - PLoS pathogens, 2020 - journals.plos.org
The COVID-19 pandemic has caused more than 575,000 deaths worldwide as of mid-July
2020 and still continues globally unabated. Immune dysfunction and cytokine storm …

Natural killer cells in antiviral immunity

NK Björkström, B Strunz, HG Ljunggren - Nature Reviews Immunology, 2022 - nature.com
Natural killer (NK) cells play an important role in innate immune responses to viral infections.
Here, we review recent insights into the role of NK cells in viral infections, with particular …

Novel coronavirus SARS-CoV-2 target and disable natural killer cells: Core immune effectors for fighting the disease

A Jewett - Critical Reviews™ in Immunology, 2020 - dl.begellhouse.com
ABSTRACT Coronavirus disease 2019 (COVID-19) poses a great public health challenge
worldwide. While studies on the effects of SARS-CoV-2 on immune cell function continue to …

NK cells: A double edge sword against SARS-CoV-2

E Masselli, M Vaccarezza, C Carubbi, G Pozzi… - Advances in biological …, 2020 - Elsevier
Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual
from microbes. They are the first line of defense against invading viruses, given their …

Natural killer cell dysfunction and its role in COVID-19

C van Eeden, L Khan, MS Osman… - International journal of …, 2020 - mdpi.com
When facing an acute viral infection, our immune systems need to function with finite
precision to enable the elimination of the pathogen, whilst protecting our bodies from …

SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis

M Lenart, M Górecka, M Bochenek… - Frontiers in …, 2023 - frontiersin.org
Introduction Natural killer (NK) cells plays a pivotal role in the control of viral infections, and
their function depend on the balance between their activating and inhibitory receptors. The …

Abnormality in the NK-cell population is prolonged in severe COVID-19 patients

G Leem, S Cheon, H Lee, SJ Choi, S Jeong… - Journal of Allergy and …, 2021 - Elsevier
Background Our understanding of adaptive immune responses in patients with coronavirus
disease 2019 (COVID-19) is rapidly evolving, but information on the innate immune …

Age-dependent NK cell dysfunctions in severe COVID-19 patients

C Fionda, S Ruggeri, G Sciumè, M Laffranchi… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are key innate effectors of antiviral immune response, and their
activity changes in ageing and severe acute respiratory syndrome coronavirus 2 (SARS …