Blood–brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches

N Marchi, T Granata, C Ghosh, D Janigro - Epilepsia, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is located within a unique anatomic interface and has
functional ramifications to most of the brain and blood cells. In the past, the BBB was …

The etiological role of blood‐brain barrier dysfunction in seizure disorders

N Marchi, W Tierney, AV Alexopoulos… - Cardiovascular …, 2011 - Wiley Online Library
A wind of change characterizes epilepsy research efforts. The traditional approach, based
on a neurocentric view of seizure generation, promoted understanding of the neuronal …

Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

E Swissa, Y Serlin, U Vazana, O Prager, A Friedman - Epilepsy & Behavior, 2019 - Elsevier
The blood–brain barrier (BBB), a unique anatomical and physiological interface between the
central nervous system (CNS) and the peripheral circulation, is essential for the function of …

Blood–brain barrier dysfunction, seizures and epilepsy

EA Van Vliet, E Aronica, JA Gorter - Seminars in cell & Developmental …, 2015 - Elsevier
The blood–brain barrier (BBB) is a dynamic and complex system which separates the brain
from the blood. It helps to maintain the homeostasis of the brain, which is essential for …

Overview and introduction: the blood–brain barrier in health and disease

NJ Abbott, A Friedman - Epilepsia, 2012 - Wiley Online Library
This article introduces the special issue on “Blood–Brain Barrier and Epilepsy.” We review
briefly current understanding of the structure and function of the blood–brain barrier (BBB) …

The blood–brain barrier and epilepsy

E Oby, D Janigro - Epilepsia, 2006 - Wiley Online Library
During the past several years, there has been increasing interest in the role of the blood–
brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to …

Breaking bad: the structure and function of the blood-brain barrier in epilepsy

H Han, A Mann, D Ekstein, S Eyal - The AAPS journal, 2017 - Springer
Epilepsy is a neurological disease with variable etiology and clinical manifestation, affecting
more than 50 million people worldwide. Although the ultimate precipitators of seizures are …

[HTML][HTML] Vascular abnormalities and the role of vascular endothelial growth factor in the epileptic brain

A Ogaki, Y Ikegaya, R Koyama - Frontiers in pharmacology, 2020 - frontiersin.org
Epilepsy is a chronic neurological disorder generally defined to be caused by excessive
neuronal activity. Thus, excessive neuronal activity is the main target of the currently used …

Cerebrovascular remodeling and epilepsy

N Marchi, M Lerner-Natoli - The Neuroscientist, 2013 - journals.sagepub.com
The role of the blood-brain barrier (BBB) in epilepsy has evolved from an obstacle for drug
brain delivery to an etiological factor contributing to seizures. Recent evidence has shown …

Blood–brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg?

A Friedman - Epilepsia, 2011 - Wiley Online Library
Status epilepticus is often associated with endothelial dysfunction and increased vessels
permeability. We discuss here the direct role of blood–brain barrier (BBB) dysfunction in …