Introduction Pulmonary inflammation and infection are important clinical and prognostic
markers of lung disease in cystic fibrosis (CF). However, whether in young children they are …

Background Cross-sectional studies implicate neutrophilic inflammation and pulmonary
infection as risk factors for early structural lung disease in infants and young children with …

Rationale: Detecting and tracking early cystic fibrosis (CF) lung disease are difficult due to
lack of sensitive markers of airway dysfunction. Objectives: The goals were to detect regional …

Background With the widespread introduction of newborn screening for cystic fibrosis (CF),
there has been considerable emphasis on the need to develop objective markers of lung …

Robroeks CMHHT, Roozeboom MH, de Jong PA, Tiddens HAWM, Jöbsis Q, Hendriks HJ,
Yntema J‐BL, Brackel HL, van Gent R, Robben S, Dompeling E. Structural lung changes …

Little is known about early predictors of later cystic fibrosis (CF) structural lung disease. This
study examined early predictors of progressive structural lung abnormalities in children who …

Background Pulmonary exacerbations in cystic fibrosis are characterized by airway
inflammation and may cause irreversible lung damage. Early identification of such …

Rationale: Better understanding of evolution of lung function in infants with cystic fibrosis
(CF) and its association with pulmonary inflammation and infection is crucial in informing …

Background Because of the heterogeneity in cystic fibrosis (CF) lung disease among young
children, a clinical method to identify early‐onset lung disease is needed. Objective To …

To identify potential risk factors for lung disease progression in children with cystic fibrosis
(CF), we studied the longitudinal data of all children with CF (aged≥ 5 years) registered in …