[HTML][HTML] Blocking IL-1 to prevent respiratory failure in COVID-19

FL Van de Veerdonk, MG Netea - Critical Care, 2020 - Springer
COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild
respiratory tract infection in the majority of individuals, but in some, it can progress into …

[HTML][HTML] Efficacy and safety of IL-6 inhibitors in patients with COVID-19 pneumonia: a systematic review and meta-analysis of multicentre, randomized trials

A Belletti, C Campochiaro, M Marmiere… - Annals of Intensive …, 2021 - Springer
Purpose COVID-19 is characterized by dysregulated immune response, respiratory failure
and a relevant mortality rate among hospitalized patients. Interleukin-6 (IL-6) is involved in …

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

M Abbasifard, H Khorramdelazad - Life sciences, 2020 - Elsevier
Abstract Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many
innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel …

[HTML][HTML] COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This …

Interleukin‐6 in COVID‐19: a systematic review and meta‐analysis

EA Coomes, H Haghbayan - Reviews in medical virology, 2020 - Wiley Online Library
Coronaviruses may activate dysregulated host immune responses. As exploratory studies
have suggested that interleukin‐6 (IL‐6) levels are elevated in cases of complicated Covid …

[HTML][HTML] The role of IL-6 in coronavirus, especially in COVID-19

X Wang, G Tang, Y Liu, L Zhang, B Chen… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects both people and
animals and may cause significant respiratory problems, including lung illness: Corona …

[HTML][HTML] Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications

J Majidpoor, K Mortezaee - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Interleukin-6 (IL-6) is a multi-tasking cytokine that represents high activity in patients
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and cancer. High …

[PDF][PDF] Cytokine-targeted therapy in severely ill COVID-19 patients: options and cautions

M Rahmati, MA Moosavi - mortality, 2020 - researchgate.net
Dear Editor, Coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV-2) with the symptoms …

Applied clinical pharmacology in a crisis: Interleukin‐6 axis blockade and COVID‐19

GW Strohbehn, PD Reid… - Clinical Pharmacology & …, 2020 - Wiley Online Library
The global pandemic of coronavirus disease 2019 (COVID‐19) represents an emergent
threat to the public health. Mitigation strategies have been employed to varying effect in …

[HTML][HTML] Immunotherapy of COVID-19: inside and beyond IL-6 signalling

G Zizzo, A Tamburello, L Castelnovo, A Laria… - Frontiers in …, 2022 - frontiersin.org
Acting on the cytokine cascade is key to preventing disease progression and death in
hospitalised patients with COVID-19. Among anti-cytokine therapies, interleukin (IL)-6 …