The activity of AP‐1, a trans‐acting transcription factor, is stimulated by 12‐O‐
tetradecanoylphorbol‐13‐acetate (TPA) and epidermal growth factor (EGF) in promotion …

Tumor promoters such as 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) and epidermal
growth factor (EGF) induce neoplastic transformation, elevated c‐jun protein expression …

The mouse benign keratinocyte cell line 308 was previously shown to have less AP‐1 DNA
binding and transactivation ability than its malignant variant 10Gy5. Because elevated AP‐1 …

Neoplastic transformation and transcriptional activation by activator protein‐1 (AP‐1)
complex are stimulated by tumor‐promoting agents in promotion‐sensitive (P+) but not …

AP-1 transcriptional activity is stimulated by the transformation promoters phorbol 12-
myristate 13-acetate (" 12-O-tetradecanoylphorbol 13-acetate," TPA) and epidermal growth …

Increased levels of c-fos and c-jun expression have been observed in differentiating
epithelial cells. However, no data are available on activator protein 1 (AP-1) activity during …

The AP‐1 transcription factor (the Jun and Fos proteins) is suspected of playing an important
role in the biology of human cancer. Human epithelial ovarian tumors and cancer cell lines …

Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun
homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter …

The JB6 mouse epidermal cell system has been used extensively as an in vitro model for the
study of tumor promotion and progression. The present study was directed to assessing the …

To understand the mechanisms regulating the transactivating activity of Jun/AP-1, we
analyzed alterations in c-Jun induced by growth stimulation and cell transformation. Serum …