The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

EC Thomson, LE Rosen, JG Shepherd, R Spreafico… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …

[HTML][HTML] Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

EC Thomson, LE Rosen, JG Shepherd, R Spreafico… - Cell, 2021 - cell.com
SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging
vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS …

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Z Liu, LA VanBlargan, LM Bloyet, PW Rothlauf… - BioRxiv, 2020 - biorxiv.org
Although neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of
most COVID-19 vaccines and being developed as therapeutics, escape mutations could …

[HTML][HTML] The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera.

S Jangra, C Ye, R Rathnasinghe, D Stadlbauer… - MedRxiv, 2021 - ncbi.nlm.nih.gov
One year in the coronavirus disease 2019 (COVID-19) pandemic, the first vaccines are
being rolled out under emergency use authorizations. It is of great concern that newly …

[HTML][HTML] SARS-CoV-2 variant B. 1.1. 7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines

X Shen, H Tang, C McDanal, K Wagh, W Fischer… - Cell host & …, 2021 - cell.com
All current vaccines for COVID-19 utilize ancestral SARS-CoV-2 spike with the goal of
generating protective neutralizing antibodies. The recent emergence and rapid spread of …

[HTML][HTML] The effect of spike mutations on SARS-CoV-2 neutralization

C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …

Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike

S Changrob, Y Fu, JJ Guthmiller, PJ Halfmann, L Li… - Mbio, 2021 - Am Soc Microbiol
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …

[HTML][HTML] SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

C Motozono, M Toyoda, J Zahradnik, A Saito… - Cell host & …, 2021 - cell.com
Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These
mutations can affect viral properties such as infectivity and immune resistance. Although the …

SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain

L Yurkovetskiy, KE Pascal, C Tomkins-Tinch, T Nyalile… - BioRxiv, 2020 - biorxiv.org
Virus genome sequence variants that appear over the course of an outbreak can be
exploited to map the trajectory of the virus from one susceptible host to another. While such …

An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity

C Motozono, M Toyoda, J Zahradnik, T Ikeda, A Saito… - BioRxiv, 2021 - biorxiv.org
During the current SARS-CoV-2 pandemic that is devastating the modern societies
worldwide, many variants that naturally acquire multiple mutations have emerged. Emerging …