Recent reports show that long non-coding RNAs (lncRNAs) have inefficient splicing and fewer alternative splice variants than mRNAs. Here, we have explored the efficiency of …
Like protein-coding genes, long noncoding RNA (lncRNA) genes are composed of introns and exons. After their transcription, lncRNAs are subject to constitutive and/or alternative …
D Staněk - Essays in biochemistry, 2021 - portlandpress.com
In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I summarize differences between the splicing efficiency of protein-coding genes and lncRNAs …
Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in …
L Yang - Wiley Interdisciplinary Reviews: RNA, 2015 - Wiley Online Library
Eukaryotic precursor‐messenger RNAs (pre‐mRNAs) undergo splicing to remove intragenic regions (introns) and ligate expressed regions (exons) together. Unlike exons in the mature …
DC Reid, BL Chang, SI Gunderson, L Alpert… - Rna, 2009 - rnajournal.cshlp.org
Many splicing factors interact with both mRNA and pre-mRNA. The identification of these interactions has been greatly improved by the development of in vivo cross-linking …
L De Conti, M Baralle, E Buratti - Wiley Interdisciplinary …, 2013 - Wiley Online Library
One of the fundamental issues in RNA splicing research is represented by understanding how the spliceosome can successfully define exons and introns in a huge variety of pre …
G Pisignano, M Ladomery - Non-coding RNA, 2021 - mdpi.com
Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is …
SD Chandler, A Mayeda, JM Yeakley… - Proceedings of the …, 1997 - National Acad Sciences
Pre-mRNA splicing requires a large number of RNA-binding proteins that have one or more RNA-recognition motifs (RRMs). Among these is the SR protein family, whose members are …