Many nascent long non-coding RNAs (lncRNAs) undergo the same maturation steps as pre-
mRNAs of protein-coding genes (PCGs), but they are often poorly spliced. To identify the …

Recent reports show that long non-coding RNAs (lncRNAs) have inefficient splicing and
fewer alternative splice variants than mRNAs. Here, we have explored the efficiency of …

Like protein-coding genes, long noncoding RNA (lncRNA) genes are composed of introns
and exons. After their transcription, lncRNAs are subject to constitutive and/or alternative …

In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I
summarize differences between the splicing efficiency of protein-coding genes and lncRNAs …

Massive high-throughput sequencing techniques allowed the identification of thousands of
noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in …

Eukaryotic precursor‐messenger RNAs (pre‐mRNAs) undergo splicing to remove intragenic
regions (introns) and ligate expressed regions (exons) together. Unlike exons in the mature …

Many splicing factors interact with both mRNA and pre-mRNA. The identification of these
interactions has been greatly improved by the development of in vivo cross-linking …

One of the fundamental issues in RNA splicing research is represented by understanding
how the spliceosome can successfully define exons and introns in a huge variety of pre …

Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of
proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is …

Pre-mRNA splicing requires a large number of RNA-binding proteins that have one or more
RNA-recognition motifs (RRMs). Among these is the SR protein family, whose members are …