An In-Silico Analysis of Drugs Potentially Modulating the Cytokine Storm Triggered by SARS-CoV-2 Infection

L Sanchez-Burgos, G Gómez-López, F Al-Shahrour… - 2020 - preprints.org
The ongoing COVID-19 pandemic is one of the biggest health and societal challenges of the
recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the …

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

L Sanchez-Burgos, G Gómez-López, F Al-Shahrour… - Scientific Reports, 2022 - nature.com
The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades.
Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an …

COVID-19: disease pathways and gene expression changes predict methylprednisolone can improve outcome in severe cases

S Draghici, TM Nguyen, LA Sonna, C Ziraldo… - …, 2021 - academic.oup.com
Motivation COVID-19 has several distinct clinical phases: a viral replication phase, an
inflammatory phase and in some patients, a hyper-inflammatory phase. High mortality is …

Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release

M Chan, S Vijay, J McNevin, MJ McElrath… - Molecular systems …, 2021 - embopress.org
Abstract Although 15–20% of COVID‐19 patients experience hyper‐inflammation induced
by massive cytokine production, cellular triggers of this process and strategies to target them …

[PDF][PDF] A Transcriptome analysis identifies potential preventive and therapeutic approaches towards COVID-19

MR Islam, A Fischer - 2020 - researchgate.net
The recent outbreak of Coronavirus Disease 2019 (COVID-19) is a major threat to human 20
health and the global economy. In addition to the development of vaccines there is an 21 …

Identification of transcriptional regulatory network associated with response of host epithelial cells to SARS-CoV-2

C Su, S Rousseau, A Emad - Scientific Reports, 2021 - nature.com
Identification of transcriptional regulatory mechanisms and signaling networks involved in
the response of host cells to infection by SARS-CoV-2 is a powerful approach that provides …

Identification of potential drug targets for COVID 19 patients with cytokine storm

BC Buana - 2022 - digital.car.chula.ac.th
The outcome of SARS-CoV-2 infection may vary depending on gender, lifestyle, and age.
The elderly is more likely to have the severe condition than the younger population …

Gene expression profiling of SARS-CoV-2 infections reveal distinct primary lung cell and systemic immune infection responses that identify pathways relevant in …

MA Moni, JMW Quinn, N Sinmaz… - Briefings in …, 2021 - academic.oup.com
To identify key gene expression pathways altered with infection of the novel coronavirus
SARS-CoV-2, we performed the largest comparative genomic and transcriptomic analysis to …

Overlapping host pathways between SARS-CoV-2 and its potential copathogens: An in silico analysis

GD Vavougios - Infection, Genetics and Evolution, 2020 - Elsevier
Background SARS-CoV-2 coinfection with other viral and bacterial pathogens and their
interactions are increasingly recognized in the literature as potential determinants of COVID …

Molecular modeling of C1‐inhibitor as SARS‐CoV‐2 target identified from the immune signatures of multiple tissues: An integrated bioinformatics study

K Sekaran, R Polachirakkal Varghese… - Cell Biochemistry …, 2023 - Wiley Online Library
The expeditious transmission of the severe acute respiratory coronavirus 2 (SARS‐CoV‐2),
a strain of COVID‐19, crumbled the global economic strength and caused a veritable …