Comparative proteomic analysis reveals the different hepatotoxic mechanisms of human hepatocytes exposed to silver nanoparticles

TY Wong, N Yan, KKL Kwan, Y Pan, J Liu… - Journal of Hazardous …, 2023 - Elsevier
Silver nanoparticles (AgNPs), which have been used extensively in consuming products and
eventually released into the natural environment, have aroused concerns recently because …

[HTML][HTML] Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic …

M Xu, Q Yang, L Xu, Z Rao, D Cao, M Gao… - Particle and fibre …, 2019 - Springer
Abstract Background Silver nanoparticles (AgNPs), as promising anti-microbials and anti-
cancer therapeutics, the toxicological effect and killing efficiency towards cells need in-depth …

Molecular and Morphological Evidence of Hepatotoxicity after Silver Nanoparticle Exposure: A Systematic Review, In Silico, and Ultrastructure Investigation

K Sooklert, A Wongjarupong, S Cherdchom… - Toxicological …, 2019 - Springer
Silver nanoparticles (AgNPs) have been widely used in a variety of applications in
innovative development; consequently, people are more exposed to this particle. Growing …

NMR metabolomics reveals metabolism-mediated protective effects in liver (HepG2) cells exposed to subtoxic levels of silver nanoparticles

J Carrola, RJB Pinto, M Nasirpour… - Journal of proteome …, 2018 - ACS Publications
The expansion of biomedical and therapeutic applications of silver nanoparticles (AgNPs)
raises the need to further understand their biological effects on human cells. In this work …

Research on the hepatotoxicity mechanism of citrate-modified silver nanoparticles based on metabolomics and proteomics

J Xie, W Dong, R Liu, Y Wang, Y Li - Nanotoxicology, 2018 - Taylor & Francis
Citrate-modified silver nanoparticles (AgNP-cit) have received extensive attention due to
their excellent antimicrobial properties. However, these particles tend to migrate in vivo …

Comparison of in vitro toxicity of silver ions and silver nanoparticles on human hepatoma cells

IV Vrček, I Žuntar, R Petlevski, I Pavičić… - Environmental …, 2016 - Wiley Online Library
Scientific information on the potential harmful effects of silver nanoparticles (AgNPs) on
human health severely lags behind their exponentially growing applications in consumer …

Silver nanoparticles induce apoptosis in HepG2 cells through particle-specific effects on mitochondria

F Wang, Z Chen, Y Wang, C Ma, L Bi… - … science & technology, 2022 - ACS Publications
Silver nanoparticles (AgNPs) have been widely used in biomedical and consumer products.
It remains challenging to distinguish the toxicity of AgNPs derived from the particle form or …

Proteomic analysis of silver nanoparticle toxicity in rat

E Kim, YC Chu, JY Han, DH Lee, YJ Kim… - Toxicology and …, 2010 - Springer
Silver nanoparticles (SNPs) have received considerable attention recently, because SNPs
with different shapes and sizes exhibit variable antimicrobial activity, which makes them …

[HTML][HTML] Hormesis effects of silver nanoparticles at non-cytotoxic doses to human hepatoma cells

ZH Jiao, M Li, YX Feng, JC Shi, J Zhang, B Shao - PloS one, 2014 - journals.plos.org
Silver nanoparticles (AgNPs) have attracted considerable attentions due to their unique
properties and diverse applications. Although it has been reported that AgNPs have acute …

Cytotoxicity and apoptosis induced by silver nanoparticles in human liver HepG2 cells in different dispersion media

Y Xue, T Zhang, B Zhang, F Gong… - Journal of Applied …, 2016 - Wiley Online Library
Abstract Silver nanoparticles (Ag NPs) have been widely used in medical and healthcare
products owing to their unique antibacterial activities. However, their safety for humans and …