Single-cell RNA sequencing reveals rebalancing of immunological response in patients with periodontitis after non-surgical periodontal therapy

H Lee, JY Joo, DH Sohn, J Kang, Y Yu, HR Park… - Journal of Translational …, 2022 - Springer
Background Periodontitis is a major inflammatory disease of the oral mucosa that is not
limited to the oral cavity but also has systemic consequences. Although the importance of …

Single-cell RNA sequencing identifies new inflammation-promoting cell subsets in Asian patients with chronic periodontitis

S Qian, Q Huang, R Chen, J Mo, L Zhou… - Frontiers in …, 2021 - frontiersin.org
Periodontitis is a highly prevalent chronic inflammatory disease leading to periodontal tissue
breakdown and subsequent tooth loss, in which excessive host immune response accounts …

Single-cell analyses of the oral mucosa reveal immune cell signatures

Y Liu, T Xu, W Jiang, Y Ma, Q Zhang… - Journal of Dental …, 2023 - journals.sagepub.com
Inflammatory bowel disease (IBD) is a common immune-related disease of the
gastrointestinal tract that affects many people around the world. Extraintestinal …

[HTML][HTML] Decoding the role of macrophages in periodontitis and type 2 diabetes using single-cell RNA-sequencing

P Agrafioti, J Morin-Baxter, KKK Tanagala… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
Macrophages are resident myeloid cells in the gingival tissue which control homeostasis
and play a pivotal role in orchestrating the immune response in periodontitis. Cell …

Immune landscape of periodontitis unveils alterations of infiltrating immunocytes and molecular networks-aggregating into an interactive web-tool for periodontitis …

X Zhang, Q Wang, X Yan, Y Shan, L Xing, M Li… - Journal of Translational …, 2020 - Springer
Background Immunity reaction plays an essential role in periodontitis progress and we aim
to investigate the underlying regulatory network of immune reactions in periodontitis …

Expression profiling and cell type classification analysis in periodontitis reveal dysregulation of multiple lncRNAs in plasma cells

D Wu, P Zhou, F Cao, Z Lin, D Liang, X Zhou - Frontiers in genetics, 2020 - frontiersin.org
Objective Periodontitis is a chronic inflammatory disease with a downregulated immune
response. The mechanisms of the immune response, especially regarding immune-related …

Differential immune cell infiltrations between healthy periodontal and chronic periodontitis tissues

W Li, Z Zhang, Z Wang - BMC Oral Health, 2020 - Springer
Background Host immunity plays an important role against oral microorganisms in
periodontitis. Methods This study assessed the infiltrating immune cell subtypes in 133 …

An update on periodontal inflammation and bone loss

M Zhang, Y Liu, H Afzali, DT Graves - Frontiers in Immunology, 2024 - frontiersin.org
Periodontal disease is a chronic inflammatory condition that affects the supporting structures
of the teeth, including the periodontal ligament and alveolar bone. Periodontal disease is …

RNA-sequencing study of peripheral blood monocytes in chronic periodontitis

YZ Liu, P Maney, J Puri, Y Zhou, M Baddoo, M Strong… - Gene, 2016 - Elsevier
Background Monocytes are an important cell type in chronic periodontitis (CP) by interacting
with oral bacteria and mediating host immune response. The aim of this study was to reveal …

Gene expression profiles in paired gingival biopsies from periodontitis-affected and healthy tissues revealed by massively parallel sequencing

H Davanian, H Stranneheim, T Båge, M Lagervall… - 2012 - journals.plos.org
Periodontitis is a chronic inflammatory disease affecting the soft tissue and bone that
surrounds the teeth. Despite extensive research, distinctive genes responsible for the …