Cu2O-Promoted cascade reaction of O-halobenzoate and enaminones for the synthesis of isoquinolinone derivatives

Y Liang, R Wang - Tetrahedron Letters, 2023 - Elsevier
A practical Cu-catalyzed cascade cyclization of o-halobenzoate with enaminones to
construct isoquinolinone derivatives is described. The process involves a Cu-catalyzed …

One-pot synthesis of isoquinoline and related compounds via Cu-mediated tandem cross-coupling and cyclization

S Dhara, R Singha, Y Nuree, JK Ray - Tetrahedron Letters, 2014 - Elsevier
One-pot synthetic strategy has been developed to access isoquinolines and its analogs via
Cu-mediated tandem cross-coupling and cyclization in good yields under mild reaction …

One-pot Synthesis of Highly Functionalizable 3-(Phenylsulfonyl)-2,3-dihydro-4(1H)-quinolinones via a Cu-catalyzed Aza-Michael Addition/Cyclization Reaction

S Kang, H Yoon, Y Lee - Chemistry Letters, 2016 - academic.oup.com
A straightforward and mild one-pot method used for the synthesis of 3-(phenylsulfonyl)-2, 3-
dihydro-4 (1 H)-quinolinones via a Cu-catalyzed aza-Michael addition/base-mediated …

Copper-catalyzed tandem cyclization to access 4-aminoquinoline derivatives

HY Sheng, H Chen, M Liao, N Peng, M Yang… - Chemistry …, 2020 - academic.oup.com
An efficient and practical method for the synthesis of 4-aminoquinoline derivatives has been
developed via copper-catalyzed cascade cyclization of 2-aminobenzonitrile and nitroolefins …

Synthesis of highly substituted quinolines via a tandem ynamide benzannulation/iodocyclization strategy

TP Willumstad, PD Boudreau… - The Journal of Organic …, 2015 - ACS Publications
A two-stage “tandem strategy” for the regiocontrolled synthesis of very highly substituted
quinolines is described. Benzannulation based on the reaction of cyclobutenones or diazo …

Divergent syntheses of 2-aminonicotinonitriles and pyrazolines by copper-catalyzed cyclization of oxime ester

Q Wu, Y Zhang, S Cui - Organic letters, 2014 - ACS Publications
Copper-catalyzed cyclization of an oxime ester toward divergent heterocycle synthesis is
reported. Oxime ester serves as an enamine precursor to cyclize with malononitrile and …

Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines

W Bao, JQ Wang, XT Xu, BH Zhang, WT Liu… - Chemical …, 2018 - pubs.rsc.org
A Cu (acac) 2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-
isocyanoacetates has been successfully developed providing an efficient strategy for the …

Synthesis of substituted 4-hydroxyalkyl-quinoline derivatives by a three-component reaction using CuCl/AuCl as sequential catalysts

KM Jiang, JA Kang, Y Jin, J Lin - Organic Chemistry Frontiers, 2018 - pubs.rsc.org
A new method to construct 4-hydroxyalkyl-quinoline derivatives is described via Cu (I) and
Au (I) sequential catalyzed cyclization of anilines with aldehyde derivatives and aliphatic …

Synthesis of isoquinoline-fused quinazolinones through Ag (I)-catalyzed cascade annulation of 2-aminobenzamides and 2-alkynylbenzaldehydes

AD Sonawane, YB Shaikh, DR Garud, M Koketsu - Synthesis, 2019 - thieme-connect.com
A new route for the expedient synthesis of a specific regioisomer of isoquinoline-fused
quinazolinones is reported. Silver (I)-catalyzed cascade cyclization of 2-aminobenzamides …

In Situ Activation of Azaarenes and Terminal Alkynes to Construct Bridged Polycyclic Compounds Containing Isoquinolinones

J Shi, Z Zhu, Z Yang, Y Lin, T Yu, M Zhong… - Organic …, 2024 - ACS Publications
A copper-catalyzed [4+ 2] cyclization reaction of isoquinolines and alkynes is developed for
the one-step construction of isoquinolinone derivatives with multisubstituted bridging rings …