Overcoming resistance to natural killer cell based immunotherapies for solid tumors

G Nayyar, Y Chu, MS Cairo - Frontiers in oncology, 2019 - frontiersin.org
Despite advances in the diagnostic and therapeutic modalities, the prognosis of several
solid tumor malignancies remains poor. Different factors associated with solid tumors …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Natural killer cells in cancer and cancer immunotherapy

H Raskov, A Orhan, A Salanti, S Gaggar, I Gögenur - cancer letters, 2021 - Elsevier
The detection and killing of neoplastic cells require coordination of a variety of antitumor
effector cells. Natural killer (NK) cells of the innate immune system are at the forefront of the …

Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

E Shin, SH Bak, T Park, JW Kim, SR Yoon… - Frontiers in …, 2023 - frontiersin.org
Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …

Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens

RW Childs, M Carlsten - Nature reviews Drug discovery, 2015 - nature.com
Scientific insights into the human immune system have recently led to unprecedented
breakthroughs in immunotherapy. In the twenty-first century, drugs and cell-based therapies …

Natural killer cells and solid tumors

A Stojanovic, A Cerwenka - Journal of innate immunity, 2011 - karger.com
Natural killer (NK) cells play an important role in the innate immune response against
cancer, in particular in the elimination of tumor metastases and small tumors. NK cell …

Killing the invaders: NK cell impact in tumors and anti-tumor therapy

M Molgora, VS Cortez, M Colonna - Cancers, 2021 - mdpi.com
Simple Summary NK cells are innate lymphoid cells involved in the control of tumor growth
and metastatic spread. Given their significant cytolytic capacity, several promising strategies …

The changing role of natural killer cells in cancer metastasis

IS Chan, AJ Ewald - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and
antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as …

Natural killer cells as a promising therapeutic target for cancer immunotherapy

N Kim, HH Lee, HJ Lee, WS Choi, J Lee… - Archives of pharmacal …, 2019 - Springer
Natural killer (NK) cells are innate lymphoid cells that provide early protection against
cancer development via their selectivity to kill abnormal cells undergoing cellular …

Innovative strategies to improve the clinical application of NK cell-based immunotherapy

M Tarannum, R Romee, RM Shapiro - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer cells constitute a part of the innate immune system that mediates an effective
immune response towards virus-infected and malignant cells. In recent years, research has …