Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Drug transporters expressed in liver and kidney play a critical role in the elimination of a
wide range of drugs and xenobiotics and inhibition of these transporters may therefore …

This white paper addresses current approaches and knowledge gaps concerning methods
to assess the role of transport proteins in drug/metabolite disposition in humans. The …

Various endogenous probes have been identified for a number of hepatic and renal drug
transporters and available clinical data indicate that they could be leveraged in phase I trials …

Drug–drug interactions are a major concern not only during clinical practice, but also in drug
development. Due to limitations of in vitro–in vivo predictions of transporter-mediated drug …

Transporters govern the access of molecules to cells or their exit from cells, thereby
controlling the overall distribution of drugs to their intracellular site of action. Clinically …

Probe drug cocktails are used clinically to assess the potential for drug–drug interactions
(DDIs), and in particular, DDIs resulting from coadministration of substrates and inhibitors of …

Drug transporters are critically important for the absorption, distribution, metabolism, and
excretion (ADME) of many drugs and endogenous compounds. Therefore, disruption of …

Many drug–drug interactions (DDI s) are based on alterations of the plasma concentrations
of a victim drug due to another drug causing inhibition and/or induction of the metabolism or …

Recently, increased interest in drug transporters and research in this area has revealed that
drug transporters play an important role in modulating drug absorption, distribution, and …