Objective The aetiology of gout is closely linked to the deposition of monosodium uric acid
(MSU) crystals and the consequent activation of the NOD-like receptor family, pyrin domain …

Objective. To investigate the effects of soluble uric acid (UA) on expression and activation of
the NOD-like receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in …

Objective Deposition of monosodium urate monohydrate (MSU) crystals in the joints
promotes an intense inflammatory response and joint dysfunction. This study evaluated the …

Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of
NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. The NLRP3 …

Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid
(MSU) crystals in tissues. The etiology of gout is directly linked to the NLRP3 inflammasome …

Monosodium urate (MSU) crystals, the etiological agent of gout, are formed in joints and
periarticular tissues due to long-lasting hyperuricemia. Although MSU crystal-triggered …

Abstract The NACHT, LRR, and PYD-domains-containing protein 3 (NLRP3) inflammasome
is an intracellular multi-protein signaling platform that is activated by cytosolic pattern …

Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation
caused by precipitation of monosodium urate crystals (MSU) in the joint. Recent studies …

Activation of the nod‐like receptor protein 3 (NLRP3) inflammasome by monosodium urate
(MSU) crystals has been identified as the molecular basis for the acute inflammatory …

Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate
(MSU) crystals in joint tissues. The nucleotide-binding oligomerization domain (NOD)-like …