Simple Summary This retrospective multicenter study examines the influence of hepatic and
extrahepatic metastases on the response of immune checkpoint blockade (ICB) in patients …

Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response
rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor …

Simple Summary The era of immune checkpoint blockade (ICB) with nivolumab and
pembrolizumab (anti-PD-1) alone or in combination with ipilimumab (anti-CTLA-4) has led to …

Background Uveal melanoma is an orphan malignancy with very limited data on treatment
options in metastatic setting. Methods In this single-center retrospective study, we describe …

Background Uveal melanoma (UM) is highly refractory to treatment with dismal prognosis in
advanced stages. The value of the combined checkpoint blockade with CTLA-4 and PD-1 …

Uveal melanoma (UM) is the most common intraocular malignancy in adults and shows a
high rate of metastatic spread. As randomized clinical trials with immune checkpoint …

Metastatic uveal melanoma (mUM) has historically been associated with short survival and
limited effective treatments. Immune checkpoint inhibitors (ICIs) have been trialed in mUM; …

Several studies have evaluated immune checkpoint inhibitors (ICIs) for metastatic uveal
melanoma; however, the efficacy of ICIs in the previous studies varied greatly. In this …

Introduction Despite recent advancements in the treatment of metastatic uveal melanoma
(UM), the availability of further treatment options remains limited and the prognosis …

Simple Summary Immune checkpoint inhibitors (ICI) have failed to overcome the high
therapy resistance of Metastatic Uveal Melanoma (MUM) in contrast to the dramatic benefits …