Introduction The mammary primordium forms during embryogenesis as a result of inductive
interactions between its constitutive tissues, the mesenchyme and epithelium, and …

The mammary gland consists of cells with gene expression patterns reflecting their cellular
origins, function, and spatiotemporal context. However, knowledge of developmental …

The mammary primordium is comprised of an aggregate of immature, undifferentiated
mammary epithelial cells and its associated mammary mesenchyme, a specialised tissue …

Embryonic mammary gland development involves the formation of mammary placodes,
invagination of flask-shaped mammary buds and development of miniature bi-layered ductal …

Background Heterogeneity within the mouse mammary epithelium and potential lineage
relationships have been recently explored by single-cell RNA profiling. To further …

The existence of mammary epithelial stem cell (MaSC) populations capable of mediating
mammary gland development and homeostasis has been established for over a decade. A …

Introduction Mammary stem cells are bipotential and suggested to be the origin of breast
cancer development, but are elusive and vaguely characterized. Breast tumors can be …

Background Understanding the molecular control of cell lineages and fate determination in
complex tissues is key to not only understanding the developmental biology and cellular …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Introduction Cancer is often suggested to result from development gone awry. Links
between normal embryonic development and cancer biology have been postulated, but no …