Tumor immunity requires border patrol to fight the enemy within | Nature Immunology Skip
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Cellular senescence is a stress response that activates innate immune cells, but little is
known about its interplay with the adaptive immune system. Here, we show that senescent …

Although cancer tends to affect the elderly, most preclinical studies are carried out in young
subjects. In this study, we developed a melanoma-specific cancer immunotherapy that …

Simple Summary Immunotherapies harness the hosts' immune system to combat cancer and
are currently used to treat many tumor types. Immunotherapies mainly target T cells, the …

Background Aging has long been thought to be a major risk factor for various types of
cancers. However, accumulating evidence indicates increased resistance of old animals to …

Aging is associated with profound changes in the human immune system, a phenomenon
referred to as immunosenescence. This complex immune remodeling affects the adaptive …

Tumor development and aging can each alter immune competence. The present study
aimed to determine the impact of Lewis lung carcinoma (LLC) presence on immune …

Cancer control by adaptive immunity involves a number of defined death,,,,,,, and clearance,,
mechanisms. However, efficient inhibition of exponential cancer growth by T cells and …

Introduction Immuno-oncology (IO) research relies heavily on murine syngeneic tumor
models. However, whilst the average age for a cancer diagnosis is 60 years or older, for …

There is a growing list of cancer immunotherapeutics approved for use in a population with
an increasing number of aged individuals. Cancer immunotherapy (CIT) mediates tumor …