Senescent cells as thermostats of antitumor immunity | Science Translational Medicine news
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Human tumors progress despite the presence of tumor associated antigen (TAA)-specific T
cells. Many different molecular and cellular mechanisms contribute to the failure of T cells to …

BETWEEN BEDSIDE AND BENCH roles in the maintenance of immune tolerance in
humans, an insight that should inform our understanding of the pathogenesis of some …

Increasing life expectancy is associated with increased cancer incidence, yet the effect of
cancer and anti-cancer treatment on elderly patients and their immune systems is not well …

Improvements in understanding cancer immunopathogenesis have now led to
unprecedented successes in immunotherapy to treat numerous cancers. Although aging is …

Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that,
in some instances, stimulates the immune clearance of senescent cells. Using an immune …

The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in
the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to …

Age-related defects of the immune system are responsible for T cell unresponsiveness to
cancer vaccination at older age. Major immune defects at older age are lack of naive T cells …

There is a clear decrease in CD8+ T cell effector function with aging, a loss once thought to
be intrinsic to the CD8+ T cells. Recent studies suggest, however, that this decline may be a …

CD8+ T cells play a central role in antitumor immune responses that kill cancer cells directly.
In aged individuals, CD8+ T cell immunity is strongly suppressed, which is associated with …