The potential of immune checkpoint inhibitors (ICI) may be limited in situations where
immune cell fitness is impaired. Here, we show that the efficacy of cancer immunotherapies …

Recent reports in oncological and non-oncological experimental setups provide strong
evidence that senescent cells are under the surveillance of CD8 T cell-mediated adaptive …

In response to a variety of cancer-inducing stresses, cells may engage a stable cell cycle
arrest mechanism, termed cellular senescence, to suppress the proliferation of preneoplastic …

Senescent and suppressor T cells are reported to be increased in select patients with cancer
and are poor prognostic indicators. Based on the association of these T cells and poor …

Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other
suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction …

Despite their key regulatory role and therapeutic potency, the molecular signatures of
interactions between T cells and antigen-presenting myeloid cells within the tumor …

Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …

Changes to innate cells, such as macrophages and myeloid‐derived suppressor cells
(MDSC s), during aging in healthy or tumor‐bearing hosts are not well understood. We …

Accumulating evidence suggests the immunosuppressive microenvironments created by
malignant tumors represent a major obstacle for effective anti‐tumor immunity. A better …

When the tumour is at bay, the CD8+ T cells come out to play | Nature Reviews Cancer Skip to
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