Cancer commonly occurs in the elderly and immunotherapy (IT) is being increasingly
applied to this population. However, the majority of preclinical mouse tumor models …

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Age is a significant risk factor for the development of cancer. However, the mechanisms that
drive age-related increases in cancer remain poorly understood. To determine if senescent …

Effective cancer immunotherapy requires overcoming immunosuppressive tumor
microenvironments. We found that local nitric oxide (NO) production by tumor-infiltrating …

CD4 T cells, and especially T follicular helper cells, are critical for the generation of a robust
humoral response to an infection or vaccination. Importantly, immunosenescence affects …

Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

The adoptive transfer of tumor-specific lymphocytes is actively being tested in the clinic for
the treatment of chronic viral infections and some types of cancer. 1, 2 In the latter setting …

Tumor-infiltrating CD8 T cells are associated with improved patient survival and response to
immunotherapy in various cancers. Persistent antigen leads to CD8 T-cell exhaustion …

Aim It is established that aging leads to declines in immune function. However, the
mechanisms underlying remain poorly understood. Methods In this study, we compared the …