Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …

Despite major advances in our understanding of adaptive immunity and dendritic cells,
consistent and durable responses to cancer vaccines remain elusive and active …

Tumor-infiltrating CD8 T cells are associated with improved patient survival and response to
immunotherapy in various cancers. Persistent antigen leads to CD8 T-cell exhaustion …

For unknown reasons, advanced age remains a dominant predictor of poor clinical outcome
for nearly all cancers. A decrease in the production of T cells by the thymus accompanies …

Aim It is established that aging leads to declines in immune function. However, the
mechanisms underlying remain poorly understood. Methods In this study, we compared the …

Aging is associated with impaired vaccine efficacy and increased susceptibility to infectious
and malignant diseases. CD8+ T‐cells are key players in the immune response against …

Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …

Simple Summary Diverse evidence revealed that CD4+ T cells play an important role in
antitumor immunity by promoting or suppressing cytotoxic T cell responses. This review …

The goal of successful anti-tumoural immunity is the development of long-term protective
immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory …

Simple Summary Despite tremendous treatment efforts, cancer is still one of the leading
causes of death, with approximately 10 million deaths in 2020. In the last decade …