Aim It is established that aging leads to declines in immune function. However, the
mechanisms underlying remain poorly understood. Methods In this study, we compared the …

Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …

Simple Summary Despite tremendous treatment efforts, cancer is still one of the leading
causes of death, with approximately 10 million deaths in 2020. In the last decade …

For unknown reasons, advanced age remains a dominant predictor of poor clinical outcome
for nearly all cancers. A decrease in the production of T cells by the thymus accompanies …

The goal of successful anti-tumoural immunity is the development of long-term protective
immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory …

Analyses of healthy tissue reveal signatures that identify resident memory CD8+ T cells
(TRM), which survey tissues without recirculating. The density of TRM phenotype cells within …

Simple Summary Diverse evidence revealed that CD4+ T cells play an important role in
antitumor immunity by promoting or suppressing cytotoxic T cell responses. This review …

Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence
that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to …

The immune system shows a decline in responsiveness to antigens both with aging, as well
as in the presence of tumors. The malfunction of the immune system with age can be …

Dendritic cells (DC) are key sentinels of the host immune response with an important role in
linking innate and adaptive immunity and maintaining tolerance. There is increasing …