Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage
Dicer, an RNase III enzyme, initiates RNA interference by processing precursor dsRNAs into
mature microRNAs and small-interfering RNAs. It is also involved in loading and activation …
mature microRNAs and small-interfering RNAs. It is also involved in loading and activation …
Structural determinants of RNA recognition and cleavage by Dicer
A hallmark of RNA interference is the production of short double-stranded RNA (dsRNA)
molecules 21–28 nucleotides in length by the specialized RNase III protein Dicer. Dicer …
molecules 21–28 nucleotides in length by the specialized RNase III protein Dicer. Dicer …
Structure of Dicer and mechanistic implications for RNAi
Dicer is a specialized ribonuclease that processes double-stranded RNA (dsRNA) into small
RNA fragments about25 nucleotides in length during the initiation phase of RNA …
RNA fragments about25 nucleotides in length during the initiation phase of RNA …
Structural insights into the advances and mechanistic understanding of human Dicer
RM Torrez, MD Ohi, AL Garner - Biochemistry, 2022 - ACS Publications
The RNase III endoribonuclease Dicer was discovered to be associated with cleavage of
double-stranded RNA in 2001. Since then, many advances in our understanding of Dicer …
double-stranded RNA in 2001. Since then, many advances in our understanding of Dicer …
Substrate-specific structural rearrangements of human Dicer
DW Taylor, E Ma, H Shigematsu… - Nature structural & …, 2013 - nature.com
Dicer has a central role in RNA-interference pathways by cleaving double-stranded RNAs
(dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double …
(dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double …
[HTML][HTML] Coordinated activities of human dicer domains in regulatory RNA processing
The conserved ribonuclease Dicer generates microRNAs and short‐interfering RNAs that
guide gene silencing in eukaryotes. The specific contributions of human Dicer's structural …
guide gene silencing in eukaryotes. The specific contributions of human Dicer's structural …
[HTML][HTML] Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
H Zhang, FA Kolb, V Brondani, E Billy… - The EMBO …, 2002 - embopress.org
Dicer is a multi‐domain RNase III‐related endonuclease responsible for processing double‐
stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA …
stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA …
Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer
D Takeshita, S Zenno, WC Lee, K Nagata… - Journal of molecular …, 2007 - Elsevier
Human Dicer contains two RNase III domains (RNase IIIa and RNase IIIb) that are
responsible for the production of short interfering RNAs and microRNAs. These small RNAs …
responsible for the production of short interfering RNAs and microRNAs. These small RNAs …
Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila
The Drosophila RNase III enzyme Dicer-2 processes double-stranded RNA (dsRNA)
precursors into small interfering RNAs (siRNAs). It also interacts with the siRNA product and …
precursors into small interfering RNAs (siRNAs). It also interacts with the siRNA product and …
Autoinhibition of human dicer by its internal helicase domain
Dicer, a member of the ribonuclease III family of enzymes, processes double-stranded RNA
substrates into∼ 21-to 27-nt products that trigger sequence-directed gene silencing by RNA …
substrates into∼ 21-to 27-nt products that trigger sequence-directed gene silencing by RNA …