Background Alterations in neurosteroid secretion have been implicated in the efficacy of
antidepressants. In a previous study, the adrenal androgen DHEA, a precursor of the …

Background: There is evidence for activation of the hypothalamus-pituitary-adrenal system
in depressed patients to be associated with increased secretion of adrenal androgens …

OBJECTIVES: The adrenal androgen dehydroepiandrosterone-sulfate (DHEA-S) seems to
be involved in the pathophysiology of depression, although its precise role in the etiology …

Background: Clinical studies of endogenous concentrations of dehydroepiandrosterone
(DHEA) and its sulfated conjugate DHEA-S in depression are limited. This study was …

Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-
S),(together DHEA [S]), are the most abundant adrenal steroids in humans and are found in …

OBJECTIVE: Clinical studies of endogenous concentrations of dehydroepiandrosterone
(DHEA) and its relation to depression are limited. This study examined whether pre-and post …

DHEA and its sulfated metabolite, DHEA-S (together abbreviated" DHEA (S)"), are the most
plentiful adrenal corticosteroids in man, yet their physiological roles remain uncertain …

OBJECTIVE: This study was designed to assess possible antidepressant effects of
dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans …

Dehydroepiandrosterone (DHEA) and its sulfate, DHEA-S, are plentiful adrenal steroid
hormones that decrease with aging and may have significant neuropsychiatric effects. In this …

Rationale. A deregulation in concentrations of the neurosteroids (allo) pregnanolone and
3α, 5α-tetrahydrodeoxycorticosterone (3α, 5α-TH DOC) has been found in depressed …