Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

Bone regeneration has long been a major focus for tissue engineers and the importance of
vascularization to the bone regeneration process has been well documented. Over the past …

Inadequate vascularization of engineered tissue constructs is a main challenge in
developing a clinically impactful therapy for large, complex, and recalcitrant bone defects. It …

One of the major challenges in tissue engineering of bone substitutes remains
vascularization of the transplant. We have developed a three-dimensional collagen-based …

Blood vessels in the mammalian skeletal system control bone formation and support
haematopoiesis by generating local niche environments. While a specialized capillary …

To introduce a functional vascular network into tissue‐engineered bone equivalents, human
endothelial colony forming cells (ECFCs) and multipotent mesenchymal stromal cells …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

Rapid vascularisation of tissue-engineered osteogenic grafts is a major obstacle in the
development of regenerative medicine approaches for bone repair. Vascular endothelial …

The generation of functional, vascularized tissues is a key challenge for the field of tissue
engineering. Before clinical implantations of such tissue engineered bone constructs can …

Bone is a highly vascularized tissue, in which vascularization and mineralization are
concurrent processes during skeletal development. Indeed, both components should be …