Lassa fever diagnostics: past, present, and future

AN Happi, CT Happi, RJ Schoepp - Current opinion in virology, 2019 - Elsevier
Highlights•An orthogonal diagnostic system with multiple assays provides the greatest
confidence in a diagnostic result.•Lateral flow immunoassays (LFIs) can significantly reduce …

Lassa virus circulating in Liberia: a retrospective genomic characterisation

MR Wiley, L Fakoli, AG Letizia, SR Welch… - The Lancet Infectious …, 2019 - thelancet.com
Background An alarming rise in reported Lassa fever cases continues in west Africa. Liberia
has the largest reported per capita incidence of Lassa fever cases in the region, but genomic …

Diagnostics for Lassa fever virus: a genetically diverse pathogen found in low-resource settings

LT Mazzola, C Kelly-Cirino - BMJ Global Health, 2019 - gh.bmj.com
Lassa fever virus (LASV) causes acute viral haemorrhagic fever with symptoms similar to
those seen with Ebola virus infections. LASV is endemic to West Africa and is transmitted …

Lassa fever—the road ahead

RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …

Laboratory diagnosis of Lassa fever

V Raabe, J Koehler - Journal of Clinical Microbiology, 2017 - Am Soc Microbiol
Lassa virus remains an important cause of illness in West Africa and among the travelers
returning from this region with an acute febrile illness. The symptoms of Lassa fever can be …

Field evaluation of a Pan-Lassa rapid diagnostic test during the 2018 Nigerian Lassa fever outbreak

ML Boisen, E Uyigue, J Aiyepada, KJ Siddle… - Scientific Reports, 2020 - nature.com
Lassa virus (LASV) is the causative agent of Lassa fever (LF), an often-fatal hemorrhagic
disease. LF is endemic in Nigeria, Sierra Leone and other West African countries. Diagnosis …

Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever

ML Boisen, JN Hartnett, JG Shaffer, A Goba… - Scientific reports, 2018 - nature.com
Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It
is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever …

Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: case report

JN Grove, LM Branco, ML Boisen, IJ Muncy… - Virology Journal, 2011 - Springer
Lassa fever is a neglected tropical disease with a significant impact on the health care
system of endemic West African nations. To date, case reports of Lassa fever have focused …

Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation

DA Asogun, DI Adomeh, J Ehimuan, I Odia, M Hass… - 2012 - journals.plos.org
Background Lassa fever is a viral hemorrhagic fever endemic in West Africa. However, none
of the hospitals in the endemic areas of Nigeria has the capacity to perform Lassa virus …

[HTML][HTML] Epidemiologic and clinical features of Lassa fever outbreak in Nigeria, January 1–May 6, 2018

EA Ilori, Y Furuse, OB Ipadeola… - Emerging infectious …, 2019 - ncbi.nlm.nih.gov
SYNOPSIS State), or the National Reference Laboratory (Federal Capital Territory).
Laboratory confirmation was performed by using RT-PCR by means of the RealStar Lassa …