In atherosclerosis and Alzheimer's disease, deposition of the altered self components
oxidized low-density lipoprotein (LDL) and amyloid-β triggers a protracted sterile …

Particulate ligands, including cholesterol crystals and amyloid fibrils, induce production of
interleukin 1β (IL-1β) dependent on the cytoplasmic sensor NLRP3 in atherosclerosis …

Atherosclerosis, the leading cause of death in developed countries, has been linked to
hypercholesterolemia for decades. More recently, atherosclerotic lesion progression has …

The CD40–CD40 ligand (CD40L) signaling axis plays an important role in immunological
pathways. Consequently, this dyad is involved in chronic inflammatory diseases, including …

Background Cluster of differentiation 36 (CD36) is a transmembrane glycoprotein involved
in many biological processes, such as platelet biology, angiogenesis and in the …

The abundant presence of macrophages and activated T cells in atherosclerotic plaques
suggests an active involvement of the immune system in this cardiovascular disease …

Atherosclerosis is a principal cause of death in the Westernized world. Previously, it was
thought to be a disease primarily involving lipid accumulation in the arterial walls. The …

Rationale: A hallmark of chronic inflammatory disorders is persistence of proinflammatory
macrophages in diseased tissues. In atherosclerosis, this is associated with dyslipidemia …

Rationale: CD40L figures prominently in chronic inflammatory diseases such as
atherosclerosis. However, since CD40L potently regulates immune function and hemostasis …

Increased levels of apolipoprotein C3 (APOC3) in the blood predict cardiovascular disease
risk in people with and without diabetes 1–4. Conversely, APOC3 loss-of-function variants …