The pathogenesis of sepsis

DJ Stearns-Kurosawa, MF Osuchowski… - Annual review of …, 2011 - annualreviews.org
Sepsis is a serious clinical condition that represents a patient's response to a severe
infection and has a very high mortality rate. Normal immune and physiologic responses …

Pathophysiology of sepsis

DG Remick - The American journal of pathology, 2007 - Elsevier
Sepsis remains a critical problem with significant morbidity and mortality even in the modern
era of critical care management. Multiple derangements exist in sepsis involving several …

Sepsis: network pathophysiology and implications for early diagnosis

J Arora, AA Mendelson… - American Journal of …, 2023 - journals.physiology.org
Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Biomarkers of inflammation and the etiology of sepsis

I Grondman, A Pirvu, A Riza, M Ioana… - Biochemical Society …, 2020 - portlandpress.com
Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a
dysregulated host response to infection. The main etiological causes of sepsis are bacterial …

The 'cytokine profile': a code for sepsis

L Ulloa, KJ Tracey - Trends in molecular medicine, 2005 - cell.com
Sepsis–the most common cause of death in hospitalized patients–affects over 18 million
people worldwide and has an expected 1% increase of incidence per year. Recent clinical …

Immune dysregulation in sepsis: experiences, lessons and perspectives

M Cao, G Wang, J Xie - Cell Death Discovery, 2023 - nature.com
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding

KN Iskander, MF Osuchowski… - Physiological …, 2013 - journals.physiology.org
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Sepsis: The evolution in definition, pathophysiology, and management

B Gyawali, K Ramakrishna… - SAGE open …, 2019 - journals.sagepub.com
There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Pathophysiologic mechanisms in septic shock

EG King, GJ Bauzá, JR Mella, DG Remick - Laboratory investigation, 2014 - nature.com
The systemic inflammatory response that occurs in the septic patient as a result of an
infectious insult affects multiple organs and systems, causing numerous physiological …