Purpose Cytokine storm, an uncontrolled overproduction of inflammatory cytokines
contributing to an aberrant systemic inflammatory response, is a major pathological feature …

Background Evidence links COVID-19 severity to hyper-inflammation. Treatment with
tocilizumab, a monoclonal antibody directed against the interleukin-6 (IL-6) receptor, was …

Objective To delineate the characteristics and clinical significance of plasma inflammatory
cytokines altered in COVID-19. Design Retrospective, single-centre cohort study. Setting …

Background and aims COVID 19 pneumonia commonly leads to ARDS. The occurrence of
ARDS in COVID 19 patients is thought to occur secondary to an exaggerated immunologic …

The prognostic value of interleukin-6 in COVID-19 needs to be clarified. In this retrospective
study, COVID-19 patients treated in Renmin Hospital of Wuhan University from Jan 7 to Feb …

Background. To investigate the association between interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐
8, and IL‐10) and the disease severity of coronavirus disease 2019 (COVID‐19). Materials …

Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated
immune state. While research has focused on the hyperinflammation, little research has …

Introduction The coronavirus pandemic has affected more than 20 million people so far.
Elevated cytokines and suppressed immune responses have been hypothesized to set off a …

Abstract Background So far, SARS-CoV-2 is the seventh coronavirus found to infect humans
and cause disease with quite a strong infectivity. Patients diagnosed as severe or critical …

The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …