Background Obesity and nonalcoholic steatohepatitis (NASH) are well-known risk factors of
hepatocellular carcinoma (HCC). The lipid-rich environment enhances the proliferation and …

MDIG is known to be overexpressed in many types of human cancers and has demonstrated
predictive power in the prognosis of cancer, although the functions and mechanisms of …

The p53 protein maintains genomic integrity through its ability to induce cell cycle arrest or
apoptosis in response to various forms of stress. Substantial regulation of p53 activity occurs …

Hepatocellular carcinogenesis is attributed to the reprogramming of cellular metabolism as a
consequence of the alteration in metabolite-related gene regulation. Identifying the …

Abstract p53 plays an important role in the regulation of the cell cycle, DNA repair, and
apoptosis and is an attractive cancer therapeutic target. Mdm2 and Mdmx are recognized as …

Mdm2 is best known as the primary negative regulator of p53, but a growing body of
evidence suggests that Mdm2 also has a number of functions independent of its role in …

AIM: To study the clinicopathological significance of p53 and mdm2 protein expression in
human pancreatic cancer. METHODS: To investigate the expression of p53 and mdm2 in …

Background & Aims: To investigate the expression and prognostic value of MACC1 in
patients with HCC and identify the mechanism by which MACC1 inhibits HCC cell apoptosis …

In the present study, the expression of P53 and MDM2 proteins were examined in
specimens from a group of 20 patients (9 with primary hepatocellular carcinoma HCC and …

Background/Aims: The transcription of mdm2 gene is activated by p53 and this limits the
growth‐suppressing activity of p53 by direct binding. It has been reported that MDM2 protein …