The influenza virus PA endonuclease, which cleaves capped host pre-mRNAs to initiate
synthesis of viral mRNA, is a prime target for antiviral therapy. The diketo acid compound L …

Emerging influenza viruses are a serious threat to human health because of their pandemic
potential. A promising target for the development of novel anti-influenza therapeutics is the …

The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric
protein complex responsible for viral RNA transcription and replication, represents a primary …

Antiviral drugs are important in preventing and controlling influenza, particularly when
vaccines are ineffective or unavailable. A single class of antiviral drugs, the neuraminidase …

The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime
viral mRNA synthesis, is a promising target for novel anti–influenza virus therapeutics. The …

The RNA-dependent RNA polymerase of influenza A virus comprises conserved and
independently-folded subdomains with defined functionalities. The N-terminal domain of the …

The influenza virus is responsible for millions of cases of severe illness annually. Yearly
variance in the effectiveness of vaccination, coupled with emerging drug resistance …

Annual unpredictable efficacy of vaccines, coupled with emerging drug resistance,
underlines the development of new antiviral drugs to treat influenza infections. The N …

Influenza virus PA endonuclease has recently emerged as an attractive target for the
development of novel antiviral therapeutics. This is an enzyme with divalent metal ion …

The clinical severity and annual occurrence of influenza virus epidemics, combined with the
availability of just a single class of antivirals to treat infections, underscores the urgent need …