Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140
S Bantia, AA Ghate, SL Ananth, YS Babu… - Antimicrobial agents …, 1998 - Am Soc Microbiol
Influenza neuraminidase (NA) plays an important role in viral replication, and
characterization of viruses resistant to NA inhibitors will help elucidate the role of active-site …
characterization of viruses resistant to NA inhibitors will help elucidate the role of active-site …
RNA and DNA hydrolysis are catalyzed by the influenza virus endonuclease
K Klumpp, L Doan, NA Roberts, B Handa - Journal of Biological Chemistry, 2000 - ASBMB
The influenza virus polymerase complex contains a metal ion-dependent endonuclease
activity, which generates short capped RNA primer molecules from capped RNA precursors …
activity, which generates short capped RNA primer molecules from capped RNA precursors …
Effects of site-specific mutation on structure and activity of influenza virus B/Lee/40 neuraminidase
X Wei, MC Els, RG Webster, GM Air - Virology, 1987 - Elsevier
A cDNA copy of the neuraminidase (NA) gene of a high-growing reassortant influenza virus
which has the hemagglutinin of B/Hong Kong/8/73 and the NA of B/Lee/40 was cloned into …
which has the hemagglutinin of B/Hong Kong/8/73 and the NA of B/Lee/40 was cloned into …
The ambiguous base-pairing and high substrate efficiency of T-705 (favipiravir) ribofuranosyl 5′-triphosphate towards influenza A virus polymerase
Z Jin, LK Smith, VK Rajwanshi, B Kim, J Deval - PloS one, 2013 - journals.plos.org
T-705 (Favipiravir) is a broad-spectrum antiviral molecule currently in late stage clinical
development for the treatment of influenza virus infection. Although it is believed that T-705 …
development for the treatment of influenza virus infection. Although it is believed that T-705 …
Disruption of the viral polymerase complex assembly as a novel approach to attenuate influenza A virus
B Mänz, V Götz, K Wunderlich, J Eisel… - Journal of Biological …, 2011 - ASBMB
To develop a novel attenuation strategy applicable to all influenza A viruses, we targeted the
highly conserved protein-protein interaction of the viral polymerase subunits PA and PB1 …
highly conserved protein-protein interaction of the viral polymerase subunits PA and PB1 …
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells
KA Bussey, EA Desmet, JL Mattiacio… - Journal of …, 2011 - Am Soc Microbiol
The 2009 pandemic influenza virus (pH1N1) is a swine-origin reassortant containing
human, avian, and swine influenza genes. We have previously shown that the polymerase …
human, avian, and swine influenza genes. We have previously shown that the polymerase …
Elucidation of Basic Mechanistic and Kinetic Properties of Influenza Endonuclease Using Chemically Synthesized RNAs (∗)
DB Olsen, F Benseler, JL Cole, MW Stahlhut… - Journal of Biological …, 1996 - ASBMB
Influenza virus utilizes a unique mechanism for initiating the transcription of viral mRNA. The
viral transcriptase ribonucleoprotein complex hydrolyzes host cell transcripts containing the …
viral transcriptase ribonucleoprotein complex hydrolyzes host cell transcripts containing the …
Identification of critical residues of influenza neuraminidase in viral particle release
JR Tisoncik, Y Guo, KS Cordero, J Yu, J Wang, Y Cao… - Virology journal, 2011 - Springer
Background Influenza neuraminidase (NA) is essential for virus release from its host cells
and it is one of the targets for structure-based antiviral drug design. Results In this report, we …
and it is one of the targets for structure-based antiviral drug design. Results In this report, we …
Structure-function studies of the influenza virus RNA polymerase PA subunit
YF Liu, ZY Lou, M Bartlam, ZH Rao - Science in China Series C: Life …, 2009 - Springer
The influenza virus RNA-dependent RNA polymerase is a heterotrimeric complex (PA, PB1
and PB2) with multiple enzymatic activities for catalyzing viral RNA transcription and …
and PB2) with multiple enzymatic activities for catalyzing viral RNA transcription and …
A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding
EZ Baum, PC Wagaman, L Ly, I Turchi, J Le, D Bucher… - Antiviral research, 2003 - Elsevier
The influenza neuraminidase (NA) inhibitors peramivir, oseltamivir, and zanamivir are potent
inhibitors of NAs from both influenza A and B strains. In general, these inhibitors are slow …
inhibitors of NAs from both influenza A and B strains. In general, these inhibitors are slow …