Pancreatic cancer is resistant to conventional therapeutic interventions, mainly due to
abundant cancer stromal cells and poor immune cell infiltration. Here, we used a targeted …

Obligate or facultative anaerobic bacteria such as Bifidobacterium, Clostridium, Salmonella,
or Escherichia coli specifically colonize and proliferate inside tumor tissues and inhibit tumor …

Bacteria-mediated tumor therapy using Salmonella enterica serovar Typhimurium is a
therapeutic option with great potential. Numerous studies explored the potential of …

We report here a tumor-targeting strategy for pancreatic cancer using a modified auxotrophic
strain of Salmonella typhimurium. The genetically-modified strain of S. typhimurium requires …

Bacterial cancer therapies aim to manipulate bacteria to effectively deploy therapeutic
payloads to tumors. Attenuated bacteria alone often cannot eradicate solid tumors …

Simple Summary The deposition of fibrotic tissue within pancreatic tumors acts as a physical
barrier to therapeutic treatment. Collagen constitutes a large part of this barrier and serves …

The present study determined the effect of the tumor‐targeting strain Salmonella
typhimurium A1‐R (S. typhimurium A1‐R) on CD8+ tumor‐infiltrating lymphocytes (TILs) in a …

The aim of the present study was to examine the efficacy of tumor-targeting Salmonella
typhimurium A1-R treatment following anti-vascular endothelial growth factor (VEGF) …

Systemic administration of Salmonella to tumor-bearing mice leads to preferential
accumulation within tumor sites and retardation of tumor growth. However, the detailed …

Cancer is a devastating disease and a large socio-economic burden. Novel therapeutic
solutions are on the rise, although a cure remains elusive. Application of microorganisms …