Liver-enriched nuclear receptors (NRs) collectively function as metabolic and toxicological
“sensors” that mediate liver-specific gene-activation in mammals. NR-mediated gene …

Nuclear receptors (NR) are ligand-modulated transcription factors that play diverse roles in
cell differentiation, development, proliferation, and metabolism and are associated with …

Nuclear receptors (NRs) are ligand-activated transcription factors that act as sensors for a
broad range of natural and synthetic ligands and regulate several key hepatic functions …

The hepatocyte is responsible for a great portion of the body's metabolic needs including the
synthesis and control of pathways involved in cholesterol, fatty acid, carbohydrate, amino …

Nuclear receptors are ligand‐activated transcriptional regulators of several key aspects of
hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety …

The nuclear receptor superfamily contains important transcriptional regulators that play
pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes …

Hepatocytes are the major cell-type in the liver responsible for the coordination of
metabolism in response to multiple signaling inputs. Coordination occurs primarily at the …

Aliment Pharmacol Ther 30, 816–825 Summary Background The important role of nuclear
receptors and their contribution to liver function in both physiological and pathological …

Members of the nuclear receptor (NR) superfamily of ligand‐activated transcription factors
are players of substantial relevance in the regulation of hepatic gene expression. NRs direct …

A comprehensive understanding of the pathways underlying hepatocyte turnover and liver
regeneration is essential for the development of innovative and effective therapies in the …