Kidney diseases manifest in progressive loss of renal function, which ultimately leads to
complete kidney failure. The mechanisms underlying the origins and progression of kidney …

The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis
in the human body. The combination of distinct, yet interrelated, molecular functions across …

The quest for the ideal therapeutic target in chronic kidney disease (CKD) has been riddled
with many obstacles stemming from the molecular complexity of the disease and its co …

Large-scale gene, protein and metabolite measurements ('omics') have driven the resolution
of biology to an unprecedented high definition. Passing from reductionism to a system …

The marked increase in research spending and individual efforts over the years on the
development of disease biomarkers, therapeutic targets and new drugs has provided a …

Integrative systems biology is an approach that brings together diverse high-throughput
experiments and databases to gain new insights into biological processes or systems at …

Transcriptome analysis and kidney research: Toward systems biology. An enormous amount
of data has been generated in kidney research using transcriptome analysis techniques. In …

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous,
and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate …

Advances in biomedical research allow for the capture of an unprecedented level of genetic,
molecular, and clinical information from large patient cohorts, where the quest for precision …

The genome-wide tools discussed in this review might define the molecular mechanism
active in each single patient with progressive kidney disease. Reflecting the individuality of …