Why do some people develop serious COVID-19 disease after infection, while others only exhibit mild symptoms?

M Ballow, CL Haga - The Journal of Allergy and Clinical Immunology: In …, 2021 - Elsevier
The year 2020 was a landmark year of a once-in-a-century pandemic of a novel coronavirus,
SARS-CoV-2 virus, that led to a rapidly spreading coronavirus disease (COVID-19). The …

[HTML][HTML] Deciphering the role of host genetics in susceptibility to severe COVID-19

ME Carter-Timofte, SE Jørgensen, MR Freytag… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following
infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst …

Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics, and perspectives—a report of the European Academy of Allergy and Clinical Immunology …

M Sokolowska, ZM Lukasik, I Agache, CA Akdis… - Allergy, 2020 - Wiley Online Library
With the worldwide spread of the novel severe acute respiratory syndrome coronavirus‐2
(SARS‐CoV‐2) resulting in declaration of a pandemic by the World Health Organization …

The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review

A Elhabyan, S Elyaacoub, E Sanad, A Abukhadra… - Virus research, 2020 - Elsevier
Background Susceptibility to severe viral infections was reported to be associated with
genetic variants in immune response genes using case reports and GWAS studies. SARS …

What we know and still ignore on COVID‐19 immune pathogenesis and a proposal based on the experience of allergic disorders

E Maggi, BG Azzarone, GW Canonica, L Moretta - Allergy, 2022 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic started in March 2020 and
caused over 5 million confirmed deaths worldwide as far August 2021. We have been …

[HTML][HTML] Immune Responses against SARS-CoV-2—Questions and Experiences

H Mangge, M Kneihsl, W Schnedl, G Sendlhofer… - Biomedicines, 2021 - mdpi.com
Understanding immune reactivity against SARS-CoV-2 is essential for coping with the
COVID-19 pandemic. Herein, we discuss experiences and open questions about the …

[HTML][HTML] The genetic risk for COVID-19 severity is associated with defective immune responses

Y Kuijpers, X Chu, M Jaeger, SJ Moorlag… - Frontiers in …, 2022 - frontiersin.org
Recent genome-wide association studies (GWASs) of COVID-19 patients of European
ancestry have identified genetic loci significantly associated with disease severity. Here, we …

Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19

AK Azkur, M Akdis, D Azkur, M Sokolowska… - Allergy, 2020 - Wiley Online Library
As a zoonotic disease that has already spread globally to several million human beings and
possibly to domestic and wild animals, eradication of coronavirus disease 2019 (COVID‐19) …

[HTML][HTML] Will a little change do you good? A putative role of polymorphisms in COVID-19

AAO Paim, A Lopes-Ribeiro, DSOD e Silva… - Immunology …, 2021 - Elsevier
An alarming disease caused by the new severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) named COVID-19 has emerged as an unprecedented public health problem …

The role of the allergist/immunologist in the COVID-19 pandemic: a Janus-faced presentation

JA Bellanti - Allergy and Asthma Proceedings, 2020 - ingentaconnect.com
Background: Following its initial description in December 2019 in Wuhan, China,
coronavirus-2 (COVID‐19) has rapidly progressed into a worldwide pandemic, affecting …