Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes
restrict DNA access. To study how TFs bind nucleosome-occupied motifs, we focused on the …

Pioneer transcription factors such as OCT4 can target silent genes embedded in
nucleosome-dense regions. How nucleosome interaction enables transcription factors to …

Transcription factor binding to genomic DNA is generally prevented by nucleosome
formation, in which the DNA is tightly wrapped around the histone octamer. In contrast …

Pioneer transcription factors are essential for cell fate changes by targeting closed
chromatin. OCT4 is a crucial pioneer factor that can induce cell reprogramming. However …

Cooperative binding of transcription factors (TFs) to chromatin orchestrates gene expression
programming and cell fate specification. However, the biophysical principles of TF …

Pioneer transcription factors have the ability to access DNA in compacted chromatin.
Multiple transcription factors can bind together to a regulatory element in a cooperative way …

Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes,
using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a …

Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell
proliferation and differentiation. It is essential for maintenance of undifferentiated, pluripotent …

Mitotic bookmarking transcription factors (BFs) maintain the capacity to bind to their targets
during mitosis, despite major rearrangements of the chromatin. While they were thought to …

Transcription factor (TF) binding to DNA is fundamental for gene regulation. However, it
remains unknown how the dynamics of TF-DNA interactions change during cell-fate …