Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling

D Schijven, D Kofink, V Tragante, M Verkerke… - Schizophrenia …, 2018 - Elsevier
Large-scale genome-wide association studies (GWAS) have implicated many low-
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …

[HTML][HTML] Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia

X Chang, LA Lima, Y Liu, J Li, Q Li, PMA Sleiman… - Frontiers in …, 2018 - frontiersin.org
Hundreds of genomic loci have been identified with the recent advances of schizophrenia in
genome-wide association studies (GWAS) and sequencing studies. However, the functional …

Boosting the power of schizophrenia genetics by leveraging new statistical tools

OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …

[PDF][PDF] Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants

JC McAfee, S Lee, J Lee, JL Bell, O Krupa, J Davis… - Cell Genomics, 2023 - cell.com
Genome-wide association studies (GWASs) have successfully identified 145 genomic
regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging …

[PDF][PDF] Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

YHH Hsu, G Pintacuda, R Liu, E Nacu, A Kim, K Tsafou… - Iscience, 2023 - cell.com
Genetics have nominated many schizophrenia risk genes and identified convergent signals
between schizophrenia and neurodevelopmental disorders. However, functional …

[PDF][PDF] Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions

SB Thyme, LM Pieper, EH Li, S Pandey, Y Wang… - Cell, 2019 - cell.com
Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

Schizophrenia Working Group of the Psychiatric … - MedRxiv, 2020 - medrxiv.org
Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …

A transcriptome-wide association study implicates specific pre-and post-synaptic abnormalities in schizophrenia

LS Hall, CW Medway, O Pain… - Human molecular …, 2020 - academic.oup.com
Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

AE Jaffe, RE Straub, JH Shin, R Tao, Y Gao… - Nature …, 2018 - nature.com
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Functional genomics identify a regulatory risk variation rs4420550 in the 16p11. 2 schizophrenia-associated locus

H Chang, X Cai, HJ Li, WP Liu, LJ Zhao, CY Zhang… - Biological …, 2021 - Elsevier
Background Genome-wide association studies (GWASs) have reported hundreds of
genomic loci associated with schizophrenia, yet identifying the functional risk variations is a …