[HTML][HTML] Diallyl trisulfide induces osteosarcoma cell apoptosis through reactive oxygen species-mediated downregulation of the PI3K/Akt pathway

H Wang, N Sun, X Li, K Li, J Tian… - Oncology …, 2016 - spandidos-publications.com
Diallyl trisulfide (DATS) is a natural organosulfur compound isolated from garlic, and has
been reported to possess anticancer activities. However, the cancer growth inhibitory effects …

Involvement of multiple signaling pathways in diallyl sulfide mediated apoptosis in mouse skin tumors

N Kalra, A Arora, Y Shukla - 2006 - journal.waocp.org
Many chemopreventive agents appear to target signaling intermediates in apoptosis-
inducing pathways. Inherently, the process of neoplastic conversion selects against …

Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells

T Hosono, T Hosono-Fukao, K Inada, R Tanaka… - …, 2008 - academic.oup.com
Alk (en) yl trisulfides (R-SSS-R′) are organosulfur compounds produced by crushed garlic
and other Allium vegetables. We found that these compounds exhibit potent anticancer …

Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-κB, and ERK-2

N Sriram, S Kalayarasan, P Ashokkumar… - Molecular and cellular …, 2008 - Springer
Chemoprevention is regarded as one of the most promising and realistic approaches in the
prevention of human cancer. Diallyl sulfide (DAS), an organosulfur component of garlic has …

Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells

D Xiao, JT Pinto, GG Gundersen, IB Weinstein - Molecular cancer …, 2005 - AACR
We previously reported that the garlic-derived compound S-allylmercaptocysteine (SAMC)
causes growth inhibition, mitotic arrest, and induction of apoptosis in SW480 human colon …

Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases

E Viry, A Anwar, G Kirsch, C Jacob… - International …, 2011 - spandidos-publications.com
For many years, in vitro and in vivo studies have reported that organosulfur compounds
(OSCs), naturally found in Allium vegetables, are able to suppress the proliferation of …

Regulation of oxidative stress–mediated apoptosis by diallyl sulfide in DMBA-exposed Swiss mice

S Prasad, N Kalra, S Srivastava… - Human & experimental …, 2008 - journals.sagepub.com
Diallyl sulfide, a sulfur-containing volatile compound present in garlic (Allium sativum),
exerts anticarcinogenic activity in various rodent tumor models. In the present study …

Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal cancer

EY Efe, A Mazumder, JY Lee, A Gaigneaux, F Radogna… - Cancer Letters, 2017 - Elsevier
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified
diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors …

Anticancer mechanism of sulfur-containing compounds

E De Gianni, C Fimognari - The Enzymes, 2015 - Elsevier
Fruit and vegetables have traditionally represented a main source for the discovery of many
biologically active substances with therapeutic values. Among the many bioactive …

Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells

A Malki, M El-Saadani, AS Sultan - Cancer biology & therapy, 2009 - Taylor & Francis
Identification of agents that are nontoxic but can delay onset and/or progression of breast
cancer, which is the main leading cause of cancer-related deaths among women, is highly …