Single-cell transcriptome profiling of tumour tissue isolates allows the characterization of
heterogeneous tumour cells along with neighbouring stromal and immune cells. Here we …

Single-cell RNA sequencing can reveal valuable insights into cellular heterogeneity within
tumour microenvironments (TMEs), paving the way for a deep understanding of cellular …

Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a
myriad of non-cancerous cell types that together with the extracellular matrix form the tumor …

Knowledge of immune cell phenotypes in the tumor microenvironment is essential for
understanding mechanisms of cancer progression and immunotherapy response. We …

Single‐cell RNA sequencing (scRNA‐seq) is a novel technology that allows transcriptomic
analyses of individual cells. During the past decade, scRNA‐seq sensitivity, accuracy, and …

Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic
resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor …

The heterogeneity and the complex cellular architecture have a crucial effect on breast
cancer progression and response to treatment. However, deciphering the neoplastic …

Genome-wide transcriptome analyses are routinely used to monitor tissue-, disease-and cell
type–specific gene expression, but it has been technically challenging to generate …

Single-cell RNA sequencing (RNA-seq) techniques can perform analysis of transcriptome at
the single-cell level and possess an unprecedented potential for exploring signatures …

Immune infiltrates in the tumor microenvironment (TME) of breast cancer (BRCA) have been
shown to play a critical role in tumorigenesis, progression, invasion, and therapy resistance …