Abstract Purpose of Review Mechanisms facilitating progression of hypertension via cross
stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed …

Angiotensin (Ang) II, the main effector of the renin–angiotensin system (RAS), is one of the
major mediators of vascular remodeling in hypertension. Besides being a potent vasoactive …

Pathogenesis of the atherosclerotic process is deemed as multi-factorial, and characterized
by chronic inflammatory response. Although hypertension is known to be one of the most …

Recent evidence shows that the renin‐angiotensin system is a crucial player in
atherosclerotic processes. The regulation of arterial blood pressure was considered from its …

The pharmacological blockade of angiotensin II actions, by angiotensin-converting enzyme
inhibitors or angiotensin receptor antagonists, results in beneficial organ protective effects …

Hypertension has been recognized as a multi-factorial trait resulting from the effect of a
combination of environmental and genetic factors, including excess dietary salt or alcohol …

Inflammation is a key feature in the initiation, progression, and clinical implications of
cardiovascular disorders, including essential hypertension. Increasing evidence shows that …

The most classical view of the renin-angiotensin system (RAS) emphasizes its role as an
endocrine regulator of sodium balance and blood pressure. However, it has long become …

Hypertension is the primary cause of cardiovascular mortality. Despite multiple existing
treatments, only half of those with the disease achieve adequate control. Therefore …

It is now well established that vascular inflammation is an independent risk factor for the
development of atherosclerosis. In otherwise healthy patients, chronic elevations of …