Determining the physiologic influences that modulate GnRH secretion, the prime initiator of
reproductive function in the human, is fundamental not only to our understanding of the rare …

Mutations in several genes have been shown to cause hypogonadotropic hypogonadism
(HHG) in humans. This condition may result from abnormalities in hypothalamic …

Failure of the normal pattern of episodic secretion of GnRH from the hypothalamus results in
the clinical syndrome of idiopathic hypogonadotropic hypogonadism (IHH), with failure of …

Hypothalamic gonadotropin releasing hormone (GnRH) is a key player in normal puberty
and sexual development and function. Genetic causes of isolated hypogonadotropic …

Molecular and Genetic Aspects of Congenital Isolated Hypogonadotropic Hypogonadism -
Endocrinology and Metabolism Clinics Skip to Main Content Advertisement Endocrinology and …

Patients with hypogonadotropic hypogonadism (HH) present with delayed puberty, infertility,
and low serum gonadotropins. The molecular basis for most cases of HH is unknown, but …

Hypogonadotropic hypogonadism is characterized by failure of gonadal function secondary
to deficient gonadotropin secretion, resulting from either a pituitary or hypothalamic defect …

Male congenital hypogonadotropic hypogonadism (CHH) is a heterogenous group of
genetic disorders that cause impairment in the production or action of gonadotropin …

Mutations in a few genes have been identified in hypogonadotropic hypogonadism (HH): the
gene KAL-1 is involved in X-linked Kallmann syndrome associated with anosmia and …

Idiopathic hypogonadotropic hypogonadism (IHH) is a condition characterized by failure to
undergo puberty in the setting of low sex steroids and low gonadotropins. IHH is due to …