CD8 plays an important role in facilitating TCR-MHC interaction, promoting Ag recognition,
and initiating T cell activation. MHC-CD8 binding kinetics have been measured in three …

Activation of the T cell receptor (TCR) on the T cell through ligation with antigen-MHC
complex of an antigen-presenting cell (APC) is an essential process in the activation of T …

Physically distinct cholesterol/sphingolipid-rich plasma membrane microdomains, so-called
lipid rafts, have been recognized to play an important regulatory role in various cellular …

Here we show that activated Th1 and Th2 cells have distinct patterns of membrane
compartmentalization into lipid rafts. TCR complex members are recruited efficiently to rafts …

The mechanism of CD8 cooperation with the TCR in antigen recognition was studied on live
T cells. Fluorescence correlation measurements yielded evidence of the presence of two …

Background: The T-lymphocyte cell-surface molecule, CD2, was the first heterophilic cell-
adhesion molecule to be discovered and has become an important paradigm for …

Both CD8 and the TCR bind to MHC class I molecules during physiologic T cell activation. It
has been shown that for optimal T cell activation to occur, CD8 must be able to bind the …

Plasma membranes of eukaryotic cells are not uniform, possessing distinct cholesterol-and
sphingolipid-rich lipid raft microdomains which constitute critical sites for signal transduction …

Highlights•Human CD1-autoreactive T cells are common and can mediate autoimmunity.•T
cell receptors can bind directly to CD1 without contacting bound lipid.•Lipids can hide buried …

While the T cell receptor (TcR) recognizes cell bound, peptide antigens embedded within
major histocompatibility complex (MHC) proteins, this interaction is not sufficient for T cell …