Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than
600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties …

The presence of unpaired copies of a gene during meiosis triggers silencing of all copies of
the gene in the diploid ascus cell of Neurospora. This phenomenon is called meiotic …

Genome defense likely evolved to curtail the spread of transposable elements and invading
viruses. A combination of effective defense mechanisms has been shown to limit …

In Neurospora crassa, genes lacking a pairing partner during meiosis are suppressed by a
process known as meiotic silencing by unpaired DNA (MSUD). To identify novel MSUD …

Cryptococcus neoformans is a human fungal pathogen with a defined sexual cycle. Nutrient-
limiting conditions and pheromones induce a dimorphic transition from unicellular yeast to …

RNA interference (RNAi) depends on the production of small RNA to regulate gene
expression in eukaryotes. Two RNAi systems exist to control repetitive selfish elements in …

In Neurospora crassa, the introduction of a transgene can lead to small interfering RNA
(siRNA)-mediated posttranscriptional gene silencing (PTGS) of homologous genes. siRNAs …

The filamentous fungus Neurospora crassa is a model organism for the study of gene
silencing. The most characterized gene silencing mechanism in this ascomycete is quelling …

Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic
transition from a unicellular yeast to multicellular hyphae during opposite sex (mating) and …

The filamentous fungus Neurospora crassa has provided a rich source of knowledge on
epigenetic phenomena that would have been difficult or impossible to gain from other …