Genistein protects epilepsy-induced brain injury through regulating the JAK2/STAT3 and Keap1/Nrf2 signaling pathways in the developing rats

Q Hu, H Yan, F Peng, W Feng, F Chen, X Huang… - European Journal of …, 2021 - Elsevier
Background Epilepsy is a common chronic neurological disease. Recurrent seizures can
cause irreversible brain damage. This study aimed to explore the regulation of Genistein on …

Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells

D Wu, Z Zheng, S Fan, X Wen… - Experimental and …, 2020 - spandidos-publications.com
Epilepsy is a prevalent neurological disorder and it is a significant health risk, affecting> 50
million people worldwide. The development of novel and appropriate strategies is required …

Melissa officinalis L. ameliorates oxidative stress and inflammation and upregulates Nrf2/HO-1 signaling in the hippocampus of pilocarpine-induced rats

HN Abd Allah, M Abdul-Hamid, AM Mahmoud… - … Science and Pollution …, 2022 - Springer
Epilepsy is characterized by recurrent epileptic seizures, and its effective management
continues to be a therapeutic challenge. Oxidative stress and local inflammatory response …

Neuroprotective effects of isoliquiritigenin against cognitive impairment via suppression of synaptic dysfunction, neuronal injury, and neuroinflammation in rats with …

X Zhu, J Liu, S Huang, W Zhu, Y Wang, O Chen… - International …, 2019 - Elsevier
Epileptogenesis is a dynamic process initiated by insults to brain and commonly
accompanied by cognitive impairment. Isoliquiritigenin (ISL), a flavonoid in licorice, has a …

Everolimus inhibits PI3K/Akt/mTOR and NF-kB/IL-6 signaling and protects seizure-induced brain injury in rats

X Huang, Q Hu, H Shi, Y Zheng, R Hu, Q Guo - Journal of Chemical …, 2021 - Elsevier
Background Epilepsy is a common chronic neurological disease caused by the over-
synchronization of neurons leading to brain dysfunction. Recurrent seizures can lead to …

Neuroprotective Effects of Idebenone Against Pilocarpine-Induced Seizures: Modulation of Antioxidant Status, DNA Damage and Na+, K+-ATPase Activity in Rat …

MAE Ahmed - Neurochemical research, 2014 - Springer
The current study investigated the neuroprotective activity of idebenone against pilocarpine-
induced seizures and hippocampal injury in rats. Idebenone is a ubiquinone analog with …

Alpha-pinene exerts antiseizure effects by preventing oxidative stress and apoptosis in the hippocampus in a rat model of temporal lobe epilepsy induced by kainate

P Hashemi, S Ahmadi - Molecular Neurobiology, 2023 - Springer
Oxidative stress and apoptosis following seizures play pivotal roles in the consequences of
repeated seizures. Beneficial effects of alpha-pinene (APN) have been reported in some …

Protection by genistein on cortical neurons against oxidative stress injury via inhibition of NF-kappaB, JNK and ERK signaling pathway

Y Qian, L Cao, T Guan, L Chen, H Xin, Y Li… - Pharmaceutical …, 2015 - Taylor & Francis
Context: Genistein, one of the isoflavones derived from soybean seeds, has been reported
to exert multiple bioactivities. However, the mechanism of its action on the central nervous …

Glycyrrhizic acid protects against temporal lobe epilepsy in young rats by regulating neuronal ferroptosis through the miR‐194‐5p/PTGS2 axis

TT Yi, LM Zhang, XN Huang - The Kaohsiung Journal of …, 2023 - Wiley Online Library
Temporal lobe epilepsy (TLE) leads to extensive degradation of the quality of life of patients.
Glycyrrhizic acid (GA) has been reported to exert neuroprotective effects on status …

Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms

N Xie, C Wang, Y Lian, C Wu, H Zhang… - Cellular and molecular …, 2014 - Springer
Puerarin extracted from Radix puerariae has been shown to exert neuroprotective effects.
However, it is still not known whether puerarin protects hippocampal neurons against cell …